

Therapeutic approaches targeting the neurotensin receptors
Malliga R. Iyer and George Kunos Expert Opin Ther Pat . 2021 May;31(5):361-386 DOI: 10.1080/13543776.2021.1866539 Abstract Introduction:...
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7월 21일3분 분량


The changing landscape of medicinal chemistry optimization
Anita Rácz, Levente M. Mihalovits, Maximilian Beckers, Nikolas Fechner, Nikolaus Stiefl, Finton Sirockin, William McCoull, Emma...
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7월 18일3분 분량


Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies
Alberto Visioli1†, Nadia Trivieri2†, Gandino Mencarelli2 , Fabrizio Giani1 , Massimiliano Copetti3 , Orazio Palumbo4 , Riccardo Pracella2...
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7월 7일3분 분량


RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus.
Xue Pang1, Lin Gu1, Qiu-Ying Han, Jia-Qing Xing, Ming Zhao, Shao-Yi Huang, Jun-Xi Yi, Jie Pan, Hao Hong Wen Xue, Xue-Qing Zhou, Zhi-Hui...
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7월 7일3분 분량


The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus
Stephanie M. Robert, Benjamin C. Reeves, Emre Kiziltug, Phan Q. Duy, Jason K. Karimy, M. Shahid Mansuri, Arnaud Marlier, Garrett...
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7월 7일2분 분량


Discovery of new LXRβ agonists as glioblastoma inhibitors
Hao Chen, Ziyang Chen, Zizhen Zhang, Yali Li, Shushu Zhang, Fuqiang Jiang, Junkang Wei, Peng Ding, Huihao Zhou, Qiong Gu, Jun Xu 2020 May...
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6월 30일3분 분량


A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting
Benjamin A. Plog, Kyungdeok Kim, Daan Verhaege, Min Woo Kim, Zachary Papadopoulos, Krikor Dikranian, Taitea Dykstra, Jay Cao, Richard J....
한울 전
6월 23일4분 분량


Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice
Bielefeld P, Martirosyan A, Martín-Suárez S, Apresyan A, Meerhoff GF, Pestana F, Poovathingal S, Reijner N, Koning W, Clement RA, Van der...

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6월 23일3분 분량


Progressive histological and behavioral deterioration of a novel mouse model of secondary hydrocephalus after subarachnoid hemorrhage.
Xuehai Deng, Jianlin Ding, Chang Liu, Zhong Wang, Junchi Wang, Qiyue Duan, Weida Li, Xinlong Chen, Xiaoping Tang & Long Zhao.Scientific...
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6월 17일2분 분량


Efficient Delivery of Lomitapide using Hybrid Membrane-Coated Tetrahedral DNA Nanostructures for Glioblastoma Therapy
Mingming Song et al. Advanced Materials , 2024 DOI: 10.1002/adma.202311760 Figure 2. Preparation and characterization of RFA NPs...
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6월 16일2분 분량


Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study.
Hanbing Xu , Masakazu Miyajima, Madoka Nakajima, Ikuko Ogino, Kaito Kawamura, Chihiro Akiba, Chihiro Kamohara, Koichiro Sakamoto,...
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6월 16일2분 분량


Increased CSF drainage by non-invasive manipulation of cervical lymphatics
Jin, H., Yoon, JH., Hong, S.P. et al. Nature (2025). https://doi.org/10.1038/s41586-025-09052-5 Abstract Cerebrospinal fluid (CSF) in...

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6월 10일5분 분량


Repositioning of Small Molecules through the Inverse Virtual Screening in silico Tool: Case of Benzothiazole-Based Inhibitors of Soluble Epoxide Hydrolase (sEH)
Erica Gazzillo, Ester Colarusso, Assunta Giordano, Maria Giovanna Chini, Marianna Potenza, Robert Klaus Hofstetter, Maria Iorizzi, Oliver...
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6월 9일3분 분량


Specific targeting of brain endothelial cells using enhancer AAV vectors
Velazquez-Rivera E, Dey O, Kim NS, Cao W, Ye Q, Gao P, Thai A, Nguyen JK, Zhang H, Ting JT, Gopi M, Ren B, Holmes TC, Xu X. Neuron. 2025...

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6월 4일4분 분량


Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis
Papadopoulos Z, Smyth LCD, Smirnov I, Gibson DA, Herz J, Kipnis J. J Exp Med. 2025 Feb 3;222(2):e20241752. doi: 10.1084/jem.20241752....
한울 전
6월 1일4분 분량


Impaired cerebrospinal fluid circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus
Dong Bin Back, Bo-Ryoung Choi, Kyoung Ja Kwon, Dong-Hee Choi, Chan Young Shin, Jongmin Lee and Hahn Young Kim Frontiers in Molecular...
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5월 26일2분 분량


TRPV4 antagonists ameliorate ventriculomegaly in a rat modelof hydrocephalus.
Alexandra E. Hochstetler, Hillary M. Smith, Daniel C. Preston, Makenna M. Reed,Paul R. Territo, Joon W. Shim, Daniel Fulkerson, Bonnie L....
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5월 26일2분 분량


Revolutionizing Peptide-Based Drug Discovery: Advances in the Post-AlphaFold Era
Chang L, Mondal A, Singh B, Martínez-Noa Y, Perez A. Wiley Interdiscip Rev Comput Mol Sci. 2024 Jan-Feb;14(1):e1693. doi: 10.1002/wcms.1693.
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5월 20일1분 분량


Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts
Leire Bejarano, Alberto J. Schuhmacher, Marinela Me´ ndez, ..., Joaquı´n Pastor, Massimo Squatrito, Maria A. Blasco Cancer Cell 32,...
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5월 19일2분 분량


Enhancing neurogenesis after traumatic brain injury: The role of adenosine kinase inhibition in promoting neuronal survival and differentiation
Campbell A, Lai T, Wahba AE, Boison D, Gebril HM. Exp Neurol. 2024 Nov;381:114930. doi: 10.1016/j.expneurol.2024.114930. Epub 2024 Aug...

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5월 12일4분 분량