

Transcriptome analysis reveals tumor microenvironment changes in glioblastoma
Hoogstrate et al Cancer Cell , 2023 https://doi.org/10.1016/j.ccell.2023.02.019 Summary A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq) (n = 322 test, n = 245 validation) on paired primary-recurrent glioblastoma resections of patients treated with the current standard of care. Transcriptional subtypes form an interconnected continuum in a two-dimensional spac
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5일 전3분 분량


ChemBounce: a computational framework for scaffold hopping in drug discovery
Woo Dae Jang, Changdai Gu, Yumi Noh, Kwang-Seok, Jae Yong Ryu https://doi.org/10.1093/bioinformatics/btaf501 Scaffold hopping is a critical strategy in medicinal chemistry for generating novel and patentable drug candidates. Here, we present ChemBounce, a computational framework designed to facilitate scaffold hopping by generating structurally diverse scaffolds with high synthetic accessibility. Given a user-supplied molecule in SMILES format, ChemBounce identifies the core
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5일 전3분 분량


Topoisomerase Regulation of Cancer Gene Expression
Laura Baranello 1,* , Fedor Kouzine 2,* and David Levens 2,* https://doi.org/10.1146/annurev-biochem-091724-010717 , Annual Review of...
한울 전
10월 10일4분 분량


Activation of the RARα attenuated CSF hypersecretion to inhibit hydrocephalus development via regulating the MAFB/MSR1 pathway
Hanhai Zeng, Kaibo Yu, Junyou Wang, Jingya Ye, Huaijun Chen, Chaoran Xu, Ting Chen, Feng Yan, Gao Chen and Chi Gu 출처 및 게재 (발행일):...
김소영
9월 29일2분 분량


Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription
Aziz Taghbalout 1,6 ∙ Chia-Hao Tung 1,6 ∙ Patricia A. Clow 2 ∙ Harianto Tjong 2 ∙ Ping Wang 2,5 ∙ Chee Hong Wong 1 ∙ Diane...
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9월 29일2분 분량


Choroid plexus CCL2‒CCR2 signaling orchestrates macrophage recruitment and cerebrospinal fluid hypersecretion in hydrocephalus.
Qiguang Wang, Fei Liu, Yue Li, Huan Zhang, Xin Qi, Ke Wu, Yi Zhang, Shenglan You, Wenke Liu, Xuhui Hui, Hanmei Li, Lei Zhu, Huile Gao,...
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9월 29일2분 분량


Pharmacogenomics of GPCR Drug Targets
Alexander S. Hauser, Sreenivas Chavali, Ikuo Masuho, Leonie J. Jahn, Kirill A. Martemyanov, David E. Gloriam, M. Madan Babu 11 January...
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9월 23일3분 분량


Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin
Pan F. Chan, Velupillai Srikannathasan, Jianzhong Huang, Haifeng Cui, Andrew P. Fosberry, Minghua Gu, Michael M. Hann, Martin Hibbs, Paul...
한울 전
9월 16일3분 분량


Brain tumoroids: Treatment prediction and drug development for brain tumors with fast, reproducible, and easy-to-use personalized models
Aurélie Soubéran, Carine Jiguet-Jiglaire, SolineToutain, Philippe Morando, Nathalie Baeza-Kallee , Romain Appay, Céline Boucard, Thomas...
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9월 11일2분 분량


Choroid plexus mast cells drive tumor-associated hydrocephalus
Yiye Li, Can Di, Shijian Song, Yubo Zhang, Yiwen Lu, Jianyou Liao, Bingxi Lei, Jian Zhong, Kaihua Guo, Nu Zhang, and Shicheng Su Cell...
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9월 8일2분 분량


Cerebrospinal fluid markers of neuroinflammation and coagulation in severe cerebral edema and chronic hydrocephalus after subarachnoid hemorrhage: a prospective study
Yuanjian Fang, Yibo Liu, Luxi Chen, Junjie Wang, Jiahao Zhang, Haocheng Zhang, Sixuan Tian, Anke Zhang, Jianmin Zhang, John H. Zhang,...
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9월 8일3분 분량


Recent Scaffold Hopping Applications in Central Nervous System Drug Discovery
Timothy B. Callis, Taylor R. Garrett, Andrew P. Montgomery, Jonathan J. Danon, Michael Kassiou* 10.1021/acs.jmedchem.2c00969 abstract The...
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9월 3일3분 분량


Effective targeting of PDGFRA-altered high-grade glioma with avapritinib
Lisa Mayr, Sina Neyazi, Kallen Schwark, ..., Carl Koschmann, Johannes Gojo, Mariella G. Filbin Cancer Cell. 2025 Apr 14;43(4):740-756.e8...
한울 전
9월 3일3분 분량


Neutrophil extracellular trap-mediated impairment of meningeal lymphatic drainage exacerbates secondary hydrocephalus after intraventricular hemorrhage
Qiang Zhang, Yujie Chen, Yingpei Li, Zhou Feng, Liang Liang, Xiaoke Hao, Wenbo Kang, Zhaoqi Zhang, Xuyang Zhang, Rong Hu, Hua Feng, Zhi...
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8월 18일2분 분량


Inhibition of histone deacetylase 6 activity mitigates neurological impairment and post-hemorrhagic hydrocephalus after intraventricular hemorrhage by modulating pyroptosis and autophagy pathways.
Hao-Xiang Wang, Zi-Ang Deng, Yuan-You Li, Jun Li, Ya-Xing Chen, Yan-Jie Zhao, Ke-Ru Huang, Wei- Ning Tian, Ai-Ping Tong, and...
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8월 18일2분 분량


Integrated proteogenomic characterization of glioblastoma evolution
Kyung-Hee Kim, Simona Migliozzi, Harim Koo, ..., Do-Hyun Nam, Antonio Iavarone, Jong Bae Park 2024, Cancer Cell 42, 358–377 DOI: ...
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8월 18일2분 분량


Recent advances in AI-driven protein-ligand interaction predictions
Jaemin Sim, Dongwoo Kim, Bomin Kim, Jieun Choi and Juyong Lee 24 February 2025 https://doi.org/10.1016/j.sbi.2025.103020 Structure-based...
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8월 11일3분 분량


Extrachromosomal DNA: An Emerging Hallmark in Human Cancer
Sihan Wu,1 Vineet Bafna,2 Howard Y. Chang,3 and Paul S. Mischel4,5 Annu. Rev. Pathol. Mech. Dis. 2022. 17:367–86...
한울 전
8월 8일3분 분량


Molecular signatures of normal pressure hydrocephalus: a large-scale proteomic analysis of cerebrospinal fluid.
Aida Kamalian, Siavash Shirzadeh Barough, Sara G. Ho, Marilyn Albert, Mark G. Luciano, Sevil Yasar Abhay Moghekar Fluids and Barriers of...
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7월 28일3분 분량


The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X. Signal Transduction and Targeted Therapy volume 8, Article number: 217 (2023) https://doi.org/10.1038/s41392-0...
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7월 21일2분 분량